OnabotulinumtoxinA, a purified natural protein, works by temporarily blocking the release of the chemical responsible for activating sweat glands. By interrupting this chemical messenger, Botox effectively reduces sweating in the treated area. The injections are shallow, placed just beneath the skin’s surface, ensuring the medication remains localized.

Studies confirm that treating excessive underarm sweating with onabotulinumtoxinA is both safe and highly effective, reducing sweating by 82-87%. Noticeable results typically appear within 2 to 4 days after treatment, with maximum effects seen around two weeks. The dryness achieved can last anywhere from 4 to 12 months, with some cases reporting benefits for up to 14 months.

Research also highlights the safety and effectiveness of repeated Botox treatments for hyperhidrosis. Patients consistently experience significant, lasting improvements in symptoms, daily activities, and overall quality of life. In addition, Botox has been shown to enhance workplace productivity for individuals affected by excessive sweating.

While sweating plays an essential role in regulating body temperature, only a small percentage of sweat glands are located in specific areas like the underarms (less than 2% of the body’s total). Temporarily stopping sweat production in these localized areas does not interfere with the body’s ability to regulate temperature. Furthermore, compensatory sweating, often associated with surgical treatments like ETS, has not been observed with Botox therapy.